Simplified Synthetic TMC-95A/B Analogues Retain the Potency of Proteasome Inhibitory Activity

Analogues of trypsin inhibitor SFTI-1 mo

Analogues of trypsin inhibitor SFTI-1 modified in the conserved P1′ position by synthetic or non-proteinogenic amino acids retain their inhibitory activity

✍ Łukajtis Rafał; Łȩgowska Anna; Wysocka Magdalena; Dȩbowski Dawid; Lesner Adam; R 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 177 KB

## Abstract A series of linear and monocyclic (with a disulfide bridge only) analogues of trypsin inhibitor SFTI‐1 modified in the P~1~ and/or P~1~′ positions were synthesized by the solid‐phase method. In the substrate specificity P~1~ position, Phe or __N__‐benzylglycine (Nphe) were introduced, w