Simplified method for intravenous dosing and serial blood sampling of unanesthetized guinea pigs

✍ Scribed by David Hochman; James Blanchard

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 248 KB
• Volume: 72
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600720841

✦ Synopsis

when the pH is lowered to 3. Since no significant particle growth has occurred, the relatively small primary particle size of the fresh gel gives a rapid rate of acid neutralization.

Phase I1 becomes more evident as the aluminum hydroxycarbonate gel ages. Both the primary particle size and the degree of aggregation increases during aging. Therefore, peptization becomes more important and the slow, second phase becomes more prominent. The rate of acid neutralization during phase I11 decreases during aging (day 2 uersus day 155 in Fig. 2), which reflects the increase in primary particle size.

An understanding of the physicochemical processes required for the in uitro acid neutralization of aluminum hydroxycarbonate gel is necessary, because similar reactions occur in the GI tract when aluminum hydroxycarbonate gel is used as an antacid.