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Simplex algorithm for the optimization of gradient elution high-performance liquid chromatography

✍ Scribed by Watson, Mark W.; Carr, Peter W.

Book ID
120393898
Publisher
American Chemical Society
Year
1979
Tongue
English
Weight
907 KB
Volume
51
Category
Article
ISSN
0003-2700

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A theoretical model is described for quick pre-optimization of binary multistep gradient elutions in liquid chromatography. This model utilizes experimental retentiontime data under isocratic elution conditions for different proportions of organic modifier in the mobile phase, and simulates the posi