Simple vs. complex inheritance of inducible aryl hydrocarbon hydroxylase in mouse tissues

✍ Scribed by Kurt Bürki; A. G. Liebelt; Edward Bresnick

• Book ID: 104784906
• Publisher: Springer
• Year: 1975
• Tongue: English
• Weight: 881 KB
• Volume: 13
• Category: Article
• ISSN: 0006-2928
• DOI: 10.1007/bf00485785

✦ Synopsis

The genetics of induction of hepatic and lung aryl hy&ocarbon hydroxylase (AHH) have been studied in Af/Ki and AKR/Ki mice and in their F1 and F2 progeny after administration of 3-methylcholanthrene (3MC). Furthermore, the induction of AHH was investigated using the fetal liver explant model system with 3MC, trans-l,2-dihydroxy-3MC, and 4'-bromoflavone as the inducers. The results obtained with the above strains were contrasted with those from the C57BL/6Ki, DBA/2+Ki, and their crosses. The present investigation revealed a complex pattern of inheritance of basal and inducible AHH in lung and liver of AKR/Ki and Af/Ki, with a poor correlation between lung and liver. Hepatic AHH was not fully inducible in the F1 hybrids, while the frequency distribution function in the ~ mice was suggestive of more than two distinct classes.