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Simple synthesis of the cis,cis and trans,trans isomers of tetrabenzo[a,c,g,i]cyclododecene (sym-tetrabenz[12]annulene)

✍ Scribed by Grohmann, Klaus; Howes, Peter David; Mitchell, Reginald Harry; Monahan, Audrey; Sondheimer, Franz

Book ID
127290174
Publisher
American Chemical Society
Year
1973
Tongue
English
Weight
304 KB
Volume
38
Category
Article
ISSN
0022-3263

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## SYNOPSIS The triphenylethylene antiestrogen trans-tamoxifen is an effective antitumor agent used in the treatment of human breast cancer. While the antiestrogenic activity of trans- tamoxifen clearly plays an important role in its tumoricidal action, some of the biological effects of trans-tamo