Simple syntheses of the polyamine alkaloid tenuilobine and analogues using selectively N-tritylated polyamines and dicarboxylic acids as bridging elements

✍ Scribed by Stratos Vassis; Ioannis Govaris; Katerina Voyagi; Petros Mamos; Dionissios Papaioannou

• Book ID: 104250762
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 152 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)00338-6

✦ Synopsis

Selectively N-tritylated spermidine and spermine derivatives and the monophenacyl ester of 1,16-hexadecanedioic acid (Hda) were used to obtain the polyamine alkaloid tenuilobine and its fully reduced analogue. Other symmetric or side-chain-shortened tenuilobine analogues were readily obtained by using Hda or its dichloride or succinic anhydride to bridge the polyamine moieties.