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Simple, Sensitive and Rapid LC–ESI–MS Method for the Quantitation of Olprinone in Rat Plasma

✍ Scribed by Jie Sun; Yan Liang; Lin Xie; An Kang; Yuan Xie; Wei-Dong Chen; Hua Lv; Guang-Ji Wang

Book ID
111790782
Publisher
Springer
Year
2007
Tongue
English
Weight
356 KB
Volume
66
Category
Article
ISSN
0009-5893

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## Abstract Sildenafil is a selective inhibitor of phosphodiesterase type 5 enzyme. A simple and sensitive LC‐MS assay was developed to determine the concentration of sildenafil in human plasma. Sildenafil and omeprazole (internal standard) were extracted from the plasma with diethyl ether. The ext