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Simple screening method for improving membrane protein thermostability

✍ Scribed by Romina Mancusso; Nathan K. Karpowich; Bryan K. Czyzewski; Da-Neng Wang

Book ID
116987309
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
549 KB
Volume
55
Category
Article
ISSN
1046-2023

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Approximately 30% of the human genome, and likewise for other genomes, encodes membrane proteins. Also, the majority of known human pharmaceutical targets are membrane proteins. As a consequence, the future success of structure-based drug-design efforts will rely heavily on membrane-protein structur