✦ LIBER ✦

Simple quantitative radioiodination of (E)-5-(2-iodovinyl)-2′-deoxyuridine (IVDU) by exchange labelling

✍ Scribed by Alfons Verbruggen; Chris Julien; Erik De Clercq; Michel De Roo

Publisher: Elsevier Science
Year: 1986
Weight: 313 KB
Volume: 37
Category: Article
ISSN: 0883-2889
DOI: 10.1016/0883-2889(86)90126-7

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✦ Synopsis

The synthesis of [125I]-(E)-5-(2-iodovinyl)-2'-deoxyuridine [( 125I]IVDU) by a halogen isotope exchange reaction has been monitored in various reaction conditions. Quantitative incorporation of radioiodine into IVDU was obtained within 20 min by a simple and safe method that is suitable for application in any nuclear medicine laboratory. The radiolabelled antiviral agent can be used without further purification.

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✍ Takashi Iwashina; Rakesh Kumar; Edward E. Knaus; Leonard I. Wiebe 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 315 KB 👁 1 views

## Abstract Radioiodinated 5‐(1‐hydroxy‐2‐iodoethyl)‐2′‐deoxyuridine (1a) and 5‐(1‐methoxy‐2‐iodoethyl)‐2′‐deoxyuridine (2a) were prepared from the corresponding unlabelled nucleosides (1 and 2) by isotope exchange in a pivalic acid melt. Compound 1a was obtained in 71.3% to 26.3% radiochemical yie