Simple Preparation of 7-Alkylamino-2-methylquinoline-5,8-diones: Regiochemistry in Nucleophilic Substitution Reactions of the 6- or 7-Bromo-2-methylquinoline-5,8-dione with Amines.
✍ Scribed by Han Young Choi; Dae Yoon Chi
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 51 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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The regioselectivity in the reaction of 6,7-dihaloquinoline-5,8-diones with amine nucleophiles was described. In this reaction the solvent played an important role.
Reaction of the title spiroactivated cyclopropane(2) with pyridine in acetonitrite yields a zwitterionic addition product. The reaction is reversible which provides conditions under which rates and equilibria constants can be obtained along with the derived activation and thermodynamic parameters o
## Abstract Oxidation of 7,8‐diaminotheophylline (1) with lead tetraacetate in refluxing toluene gave a mixture of 3‐amino‐5,7‐dimethylpyrimido[4,5‐__e__][1,2,4]triazine‐6,8‐dione (**2**) and 6‐cyanoimino‐5‐diazo‐1,3‐dimethylpyrimidine‐2,4‐dione (**4**). The latter was transformed to **2** by the r