✦ LIBER ✦

Simple microwave-assisted ligand-free suzuki cross-coupling: Functionalization of halo-pyrimidine moieties

✍ Scribed by Matteo Colombo; Marco Giglio; Ilaria Peretto

Publisher: Journal of Heterocyclic Chemistry
Year: 2008
Tongue: English
Weight: 291 KB
Volume: 45
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570450420

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✦ Synopsis

Abstract

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An advantageous ligand‐free protocol for Suzuki couplings is described. The synthetic procedure entails microwave irradiation for the reduction of the reaction times and the use of silica cartridges for the purification. Dihalo‐pyrimidine structures, interesting scaffolds in medicinal chemistry, were chosen as test compounds.

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