𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Simple machine-assisted protocol for solid-phase synthesis of depsipeptides

✍ Scribed by Jan Spengler; Beate Koksch; Fernando Albericio

Publisher
Wiley (John Wiley & Sons)
Year
2007
Tongue
English
Weight
152 KB
Volume
88
Category
Article
ISSN
0006-3525

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A straightforward machine‐assisted protocol for the synthesis of linear depsipeptides is reported. The synthesis was performed on a 433A Peptide Synthesizer (Applied Biosystems) using preprogrammed and optimized modules for Boc chemistry and without any need for hardware modification. The robustness of the protocol was demonstrated with 12 examples of 26‐membered depsipeptides with single and multiple (up to 6) ester backbone substitutions. © 2007 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 88: 823–828, 2007.

This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at [email protected]

📜 SIMILAR VOLUMES

The depsipeptide method for solid-phase
The depsipeptide method for solid-phase synthesis of difficult peptides
✍ Irene Coin 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 244 KB

## Abstract After about one century of peptide chemistry, the main limitation to the accessibility of peptides and proteins via chemosynthesis is the arising of folding and aggregation phenomena. This is true not only for sequences above a critical length but also for several biologically relevant

Microwave-assisted solid-phase synthesis
Microwave-assisted solid-phase synthesis of 2,4,5-triaryl imidazoles in solventless system: An improved protocol
✍ Hossein A. Oskooie; Zahra Alimohammadi; Majid M. Heravi 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 210 KB

## Abstract The solventless microwave‐assisted synthesis of 2,4,5‐triaryl imidazoles from 1,2‐diphenylethandione or 2‐hydroxy‐1,2‐diphenylethanone in the presence of NH~4~OAc/NaHSO~4~ supported onto silica gel under microwave irradiation is reported. © 2006 Wiley Periodicals, Inc. Heteroatom Chem 1