Simple fragment syntheses of all four isomers of the spermine alkaloid kukoamine

✍ Scribed by George Karigiannis; Petros Mamos; George Balayiannis; Ioannis Katsoulis; Dionissios Papaioannou

• Book ID: 104259455
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 303 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)00940-x

✦ Synopsis

All four isomers of the spermine alkaloid kukoamine were unambiguously prepared through diacylation with O,O'-dibenzylcaffeyl chloride of suitably protected (benzyl and/or trityl groups) spermine derivatives, assembled on solid and/or in liquid phase using 1%alanine and y-aminobutyric acid, followed by simultaneous N-and 0 deprotection and double bond reduction using catalytic hydrogenation.