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Simple estimation of the conformational homogeneity of 2,5-disubstituted-1,3-dithianes by means of their 1H NMR spectra

✍ Scribed by Piotr P. Graczyk; Marian Mikolajczyk

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
380 KB
Volume
30
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

A simple method for the correction of free energy differences, Δ__G__°~exp~, obtained via the equilibriation of 2‐substituted 5‐tert‐butyl‐1,3‐dithianes, is proposed on the basis of the ^1^H NMR data for diastereoisomers. It suggests, in contrast to the opinion of other workers, that these derivatives can be used in order to establish the preference of a substituent connected to the anomeric carbon atom. A simple procedure for the comparison of the amount of twist‐boat forms is also demonstrated.

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