## Abstract Loss of the Y chromosome in bone marrow (BM) cells is a normal ageโassociated event. Y chromosome loss is also observed in the Philadelphia chromosome (Ph) positive BM cells of some patients with chronic myeloid leukemia (CML) in chronic phase, but at a younger age than in normal indivi
Simple and reliably sensitive diagnosis and monitoring of Philadelphia chromosome-positive cells in chronic myeloid leukemia by interphase fluorescence in situ hybridization of peripheral blood cells
โ Scribed by Yanagi, M; Shinjo, K; Takeshita, A; Tobita, T; Yano, K; Kobayashi, M; Terasaki, H; Naoe, T; Ohnishi, K; Ohno, R
- Book ID
- 110054176
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 209 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0887-6924
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## Abstract Interphase fluorescence in situ hybridization (IโFISH) studies have a remarkable prognostic value in patients with chronic lymphocytic leukemia (CLL). IโFISH studies can be performed either on tetradecanoylphorbol acetate stimulated peripheral blood cells (IโFISHโTPA) or unstimulated pe