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Simple and inexpensive threonine-based organocatalysts for the highly diastereo- and enantioselective direct large-scale syn-aldol and anti-Mannich reactions of α-hydroxyacetone

✍ Scribed by Chuanlong Wu; Xiangkai Fu; Shi Li


Book ID
113929497
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
975 KB
Volume
22
Category
Article
ISSN
0957-4166

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Threonine-surfactant organocatalysts for
✍ Chuanlong Wu; Xiangkai Fu; Xuebing Ma; Shi Li; Chao Li 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 286 KB

In this work, several new L-threonine derivatives as organocatalysts were synthesized in one step for the first time by the reaction of threonine with acyl chlorides at room temperature in trifluoroacetic acid on a large-scale without protecting groups involved or chromatographic techniques, and tho