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Simple and highly efficient synthesis of 3′-deoxy-3′-[18F]fluorothymidine using nucleophilic fluorination catalyzed by protic solvent

✍ Scribed by Sang Ju Lee; Seung Jun Oh; Dae Yoon Chi; Hee Seup Kil; Euy Nyong Kim; Jin Sook Ryu; Dae Hyuk Moon


Publisher
Springer
Year
2007
Tongue
English
Weight
94 KB
Volume
34
Category
Article
ISSN
0340-6997

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Comparison of synthesis yields of 3′-deo
✍ Sang Ju Lee; Seung Jun Oh; Dae Yoon Chi; Byoung Se Lee; Jin Sook Ryu; Dae Hyuk M 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 105 KB

## Abstract [^18^F]Fluorothymidine ([^18^F]FLT) is synthesized with a high radiochemical yield by nucleophilic substitution in protic solvent. In this study, we compared [^18^F]fluorination yields of [^18^F]fluorothymidine ([^18^F]FLT) in various alcohol solvents: 3,3‐dimethyl‐1‐butanol, 2‐trifluor