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Simple and convenient access to α,α,α-trisubstituted amides by double addition of Grignard reagents to acyl cyanohydrins

✍ Scribed by Boukattaya, Fatma; Stanovych, Andrii; Setzer, Paul; Abid, Souhir; Ammar, Houcine; Pearson-Long, Morwenna S. M.; Bertus, Philippe

Book ID
120006229
Publisher
Royal Society of Chemistry
Year
2012
Tongue
English
Weight
696 KB
Volume
48
Category
Article
ISSN
1359-7345

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✍ Ruifang Wang; Brian T. Gregg; Wei Zhang; Kathryn C. Golden; John F. Quinn; Peng 📂 Article 📅 2009 🏛 Elsevier Science 🌐 French ⚖ 567 KB

A series of carbinamines (a,a,a-trisubstituted amines) have been prepared in a simple and efficient onepot procedure by the addition of Grignard reagents to a series of aliphatic, aromatic and heteroaromatic nitriles. The resulting magnesium imines are subsequently converted to the desired amine aft