Simple and chemoselective reduction of aromatic nitro compounds to aromatic amines: reduction with hydriodic acid revisited

✍ Scribed by J.S.Dileep Kumar; ManKit M Ho; Tatsushi Toyokuni

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 82 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)01083-8

✦ Synopsis

Reduction of aromatic nitro compounds to amines with hydriodic acid was reinvestigated. Under a milder non-refluxing condition (at 90°C for 2-4 h), the reduction proceeded efficiently with excellent chemoselectivity without affecting other functional groups including nitrile, ester, halide, carbonyl, amide, sulfonamide, imidazole and methylthio groups.