Simple 1,2-Diamine Ligands for Asymmetric Addition of Aryllithium Reagents to Imines

✍ Scribed by Noemi Cabello; Jean-Claude Kizirian; Ségolène Gille; Alexandre Alexakis; Gérald Bernardinelli; Laurent Pinchard; Jean-Claude Caille

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 138 KB
• Volume: 2005
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.200500447

✦ Synopsis

Abstract

Enantioselective addition of various aryllithium reagents to aromatic imines was catalyzed (20 mol‐%) by readily accessible 1,2‐diamines to afford a wide range of protected diarylmethylamines in up to 94 % enantiomeric excess. Furthermore, the absolute configuration of these arylation products was determined by using X‐ray crystallography. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)