Similarity between natural and recombinant human alpha-fetoprotein as inhibitors of estrogen-dependent breast cancer growth

Recombinant insulin-like growth factor b

Recombinant insulin-like growth factor binding protein-1 inhibits IGF-I, serum, and estrogen-dependent growth of MCF-7 human breast cancer cells

✍ José A. Figueroa; Jivesh Sharma; James G. Jackson; Martin J. McDermott; Susan G. 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 942 KB

## Abstract The insulin‐like growth factors (IGFs) are potent mitogens for breast cancer cells and their activity is modulated by high affinity binding proteins (IGFBPs). We have recently shown that IGFBP‐1 purified from human amniotic fluid neutralizes IGF‐I‐dependent growth of MCF‐7 cells. In thi