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Similar dynamics of G-protein coupled receptors molecules in response to antagonist binding

✍ Scribed by Jaak Järv; Aldo Oras


Book ID
116767240
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
56 KB
Volume
373
Category
Article
ISSN
0304-3940

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A model of non-exclusive binding of agon
✍ Jaak Järv 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 330 KB

A modified concept of functioning of G-protein coupled receptors is presented, on the assumption that agonistic and antagonistic effects of drugs are related to their interaction with two separate receptor sites that exist simultaneously on a single receptor molecule and possess different ligand-spe