## Abstract Serum antibodies are widely utilised as specific and sensitive markers of virus infections but they have been employed relatively infrequently in the investigation of simian virus 40 (SV40) as a human carcinogen. In the past few years, serological data have become available which allow
Simian virus 40, poliovaccines and human tumors: a review of recent developments
โ Scribed by Carbone, Michele; Rizzo, Paola; Pass, Harvey I
- Book ID
- 110060959
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 792 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0950-9232
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๐ SIMILAR VOLUMES
Simian virus 40 (SV40), a monkey polyomavirus, was a contaminant of early poliovirus vaccines administered to millions of individuals in the 1950s and early 1960s. SV40 causes brain tumors in laboratory animals, and SV40 DNA sequences have been variably identified in human choroid plexus tumors and
SV40 DNA sequences have been found in human tumors, such as mesotheliomas, ependymomas, and bone tumors, suggesting that SV40 may be involved in their etiology. The FOS oncogene could play an important role in bone development because SV40 is able to induce FOS in cell culture. In this study, the pr
## Abstract Tumors induced by SV40 virus in newborn and adult Syrian hamsters were analyzed for their growth properties in vitro, transplantation, agglutination with concanavalin A and chromosome constitution. Following transfer to culture flasks tumor cells grew for 2โ3 weeks, then went through a