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Simian lentiviral vector-mediated retinal gene transfer of pigment epithelium-derived factor protects retinal degeneration and electrical defect in Royal College of Surgeons rats

✍ Scribed by Miyazaki, M; Ikeda, Y; Yonemitsu, Y; Goto, Y; Sakamoto, T; Tabata, T; Ueda, Y; Hasegawa, M; Tobimatsu, S; Ishibashi, T

Book ID: 110039327
Publisher: Nature Publishing Group
Year: 2003
Tongue: English
Weight: 347 KB
Volume: 10
Category: Article
ISSN: 0969-7128
DOI: 10.1038/sj.gt.3302028

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## Abstract ## Background We previously demonstrated that a new lentiviral vector derived from nonpathogenic simian immunodeficiency virus (SIVagm) was efficient and safe for long‐lasting retinal gene transfer, and that it provided the significant therapeutic effect of expressing human pigment epi