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Silyl phosphites. I. Reaction of silyl phosphites with diphenyl disulfide. Synthesis of S-phenyl nucleoside phosphorothioates

✍ Scribed by Hata, Tsujiaki; Sekine, Mitsuo


Book ID
118257344
Publisher
American Chemical Society
Year
1974
Tongue
English
Weight
244 KB
Volume
96
Category
Article
ISSN
0002-7863

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Asymmetric synthesis of 8-lactams by means of the reaction of dimethylketene silyl acetal with (S)-alkylidenetl-arylethyl)amines in the presence of titanium tetrachloride was studied. The extent of the asymmetric induction was in the range of 44-78% (diastereomeric purity 72-898) and the (S)-configu