Silyl modification of biologically active compounds. 12. Silyl group as true incentive to antitumour and antibacterial action of choline and colamine analogues
✍ Scribed by Alla Zablotskaya; Izolda Segal; Yuris Popelis; Edmunds Lukevics; Shipra Baluja; Irina Shestakova; Ilona Domracheva
- Book ID
- 101569400
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 165 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0268-2605
- DOI
- 10.1002/aoc.1133
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✦ Synopsis
Abstract
A series of triorganylsilyl(β‐dialkylaminoethoxy)silanes was prepared and characterized by elemental analysis, ^1^H, ^13^C, ^29^Si NMR and mass spectroscopy. Comparative study of ^29^Si resonance of newly synthesized compounds showed correlation between its value and substituent nature at the silicon atom, and is shifted upfield for β‐triorganyl(N,N‐dialkylaminoethoxy)silanes in comparison with corresponding methiodides, revealing weak N^…^Si interaction for proper silanes. In vitro antitumour and antimicrobial properties were investigated. The biological activity data exhibited a marked enhancement of inhibitory activity on trialkylsilylation against tumour cell lines and all the test bacterial/fungal strains. Copyright © 2006 John Wiley & Sons, Ltd.