Silicone crosslinked by ionizing radiation as potential polymeric matrix for drug delivery

✍ Scribed by Sizue O. Rogero; José S. Sousa; Dante Alário Jr.; Lilian Lopérgolo; Ademar B. Lugão

• Book ID: 103859390
• Publisher: Elsevier Science
• Year: 2005
• Tongue: English
• Weight: 168 KB
• Volume: 236
• Category: Article
• ISSN: 0168-583X
• DOI: 10.1016/j.nimb.2005.04.031

✦ Synopsis

This work describes the use of a catalysis-free system for crosslinking of silicone. Biomedical Grade silicone was crosslinked by ionizing radiation and the physico-chemical and biocompatibility properties of the resulting material were evaluated. High gel content (>90%) was obtained at the irradiation dose of 25 kGy, as indicated by gel fraction measurements. Swelling measurements showed a trend towards stabilization of crosslinking at 75 kGy. DMTA measurements showed that crystallization was impaired by the crosslinking reaction. The in vitro cytotoxicity data showed that radiation-induced crosslinking and degradation did not promote any toxicity in irradiated silicone.