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Silicon directed asymmetric synthesis of (1R, 2S)-(−)-(1,2-Epoxypropyl)phosphonic acid (fosfomycin) from (S)-lactaldehyde

✍ Scribed by Elisa Bandini; Giorgio Martelli; Giuseppe Spunta; Mauro Panunzio


Book ID
103977249
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
253 KB
Volume
6
Category
Article
ISSN
0957-4166

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An efficient and easy one-pot reaction from readily available racemic 2-substituted cyclobutanones gave, by means of asymmetric Strecker synthesis in the presence of an amine chiral auxiliary, two major aminonitriles with excellent diastereoselectivity. After separation, the major cis-aminonitriles