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Silicon chip-based patch-clamp electrodes integrated with PDMS microfluidics

โœ Scribed by Rigo Pantoja; John M. Nagarah; Dorine M. Starace; Nicholas A. Melosh; Rikard Blunck; Francisco Bezanilla; James R. Heath

Book ID
108071585
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
301 KB
Volume
20
Category
Article
ISSN
0956-5663

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Poly(dimethylsiloxane) (PDMS) has been used as an attractive material for planar patch-clamp system fabrication. However, the hydrophobic property of PDMS prevents the establishment of a high-resistance seal with cell membrane. Here, we describe the first use of poly(ethylene glycol) (PEG)/SU-8 mixt