𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Silicate Cross-Linked Bio-Nanocomposite Hydrogels from PEO and Chitosan

✍ Scribed by Qu Jin; Patrick Schexnailder; Akhilesh K. Gaharwar; Gudrun Schmidt

Book ID
102934326
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
518 KB
Volume
9
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

The compositions and the multi phase structures of bio‐nanocomposite hydrogels made from silicate cross‐linked PEO and chitosan are related to some of their physical and biological properties. The gels are injectable and self‐healing because the cross‐linking is physical and reversible under deformation. The presence of chitosan aggregates affects the viscoelastic properties and reinforces the hydrogel network. The chitosan adds advantageous properties to the hydrogel such as enhanced cell spreading and adhesion. In vitro biocompatibility data indicate that NIH 3T3 fibroblasts grow and proliferate on the bio‐nanocomposite hydrogel as well as on hydrogel films.

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✍ Huiqun Yu; Jun Lu; Chaobo Xiao 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 355 KB

## Abstract In this paper, a novel composite hydrogel was prepared by the use of dialdehyde konjac glucomannan (DAK) as macromolecular cross‐linking agent for chitosan (CS). This biocompatible material cross‐links and gels in minutes. The structure and morphology were characterized by various analy