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Silica-bound benzoyl chloride mediated the solid-phase synthesis of 4H-3,1-benzoxazin-4-ones

โœ Scribed by Rad-Moghadam, Kurosh; Rouhi, Somayeh


Book ID
120317268
Publisher
Beilstein Institut
Year
2009
Tongue
English
Weight
207 KB
Volume
5
Category
Article
ISSN
1860-5397

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Solid-phase combinatorial synthesis of 1
โœ Cheng Leng Lee; Kok Ping Chan; Yulin Lam; Soo Ying Lee ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 82 KB

The first solid-phase synthesis of 1,4-benzothiazin-3(4H)-ones and 1,4-benzoxazin-3(4H)-ones is reported. Alkylation of the immobilized 4-hydroxy-3-nitrobenzamide 2a and 3-nitro-4-sulfanylbenzamide 2b, followed by reduction and cyclization gave 4. Further alkylation and acylation was performed on th