Solid-phase combinatorial synthesis of 1
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Cheng Leng Lee; Kok Ping Chan; Yulin Lam; Soo Ying Lee
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Article
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2001
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Elsevier Science
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French
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The first solid-phase synthesis of 1,4-benzothiazin-3(4H)-ones and 1,4-benzoxazin-3(4H)-ones is reported. Alkylation of the immobilized 4-hydroxy-3-nitrobenzamide 2a and 3-nitro-4-sulfanylbenzamide 2b, followed by reduction and cyclization gave 4. Further alkylation and acylation was performed on th