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Silencing the MET oncogene leads to regression of experimental tumors and metastases

โœ Scribed by Corso, S; Migliore, C; Ghiso, E; De Rosa, G; Comoglio, P M; Giordano, S


Book ID
110072687
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
278 KB
Volume
27
Category
Article
ISSN
0950-9232

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In head and neck squamous cell carcinomas (HNSCC), metastasis to cervical lymph nodes is a major determinant of patient outcome. To detect metastases, we used the MET oncogene as marker, which encodes the receptor for hepatocyte growth factor/scatter factor, mediating epithelial cell motility and in