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Silencing of tumor suppressor genes RASSF1A, SLIT2, and WIF1 by promoter hypermethylation in hereditary breast cancer

✍ Scribed by Carolina Alvarez; Teresa Tapia; Valeria Cornejo; Wanda Fernandez; Alex Muñoz; Mauricio Camus; Manuel Alvarez; Luigi Devoto; Dr. Pilar Carvallo

Book ID
112142393
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
366 KB
Volume
52
Category
Article
ISSN
0899-1987

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## Abstract The putative tumor suppressors __RASSF1A__ and __BLU__ are mapped adjacent to one another on chromosome 3p21.3, a region frequently deleted in lung cancer. These genes are often inactivated by promoter hypermethylation, but the association of this inactivation with clinical features of