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Silencing of TLR4 Decreases Liver Tumor Burden in a Murine Model of Colorectal Metastasis and Hepatic Steatosis

โœ Scribed by T. M. Earl; I. B. Nicoud; J. M. Pierce; J. P. Wright; N. E. Majoras; J. E. Rubin; K. P. Pierre; D. L. Gorden; R. S. Chari


Book ID
111772886
Publisher
Springer
Year
2009
Tongue
English
Weight
476 KB
Volume
16
Category
Article
ISSN
1068-9265

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## This investigation aimed to develop a biologically relevant murine model of colorectal liver metastases and determine if Kupffer cells (KC) and hepatic natural killer cells (hNKC) regulate tumor growth. The model involves the injection of murine colon adenocarcinoma 26 (MCA 26) tumor cells into t