𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Silencing of sigma-1 receptor induces cell death in human lens cells

✍ Scribed by Lixin Wang; George Duncan

Book ID
118506381
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
453 KB
Volume
312
Category
Article
ISSN
0014-4827

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## Abstract Insulin receptor substrate 1 (IRS‐1) is a major downstream signaling protein for insulin and insulin‐like growth factor I (IGF‐I) receptors, conveying signals to PI‐3K/Akt and ERK1/2 pathways. In breast cancer, IRS‐1 overexpression has been associated with tumor development, hormone‐ind