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Silencing of Polo-Like Kinase (Plk) 1 via siRNA Causes Inhibition of Growth and Induction of Apoptosis in Human Esophageal Cancer Cells

✍ Scribed by Bu, Youquan; Yang, Zhengmei; Li, Quanhai; Song, Fangzhou

Book ID: 119984970
Publisher: S. Karger AG
Year: 2008
Tongue: English
Weight: 428 KB
Volume: 74
Category: Article
ISSN: 0030-2414
DOI: 10.1159/000151367

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## Abstract The type 1 insulin-like growth factor receptor (IGF-1R), which is over-expressed or activated in many human cancers, including lung cancer, mediates cancer cell proliferation and metastasis. Several studies indicate that blocking IGF-1R expression can inhibit tumor cell proliferation an