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Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo

โœ Scribed by Chen, Z Y; He, C Y; Meuse, L; Kay, M A

Book ID
110039524
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
282 KB
Volume
11
Category
Article
ISSN
0969-7128

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To examine the effects of inflammatory response to plasmid DNA (pDNA) on transgene expression, serum tumor necrosis factor-a (TNF-a) was measured after intravenous injection of pDNA or calf thymus DNA (CT DNA) in the naked or complexed form with cationic liposomes (lipoplex). pDNA with many CpG moti