Silencing of African horse sickness virus VP7 protein expression in cultured cells by RNA interference

Silencing of choline acetyltransferase e

Silencing of choline acetyltransferase expression by lentivirus-mediated RNA interference in cultured cells and in the adult rodent brain

✍ Julie Santamaria; Olfa Khalfallah; Claire Sauty; Isabelle Brunet; Mathieu Sibieu 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 816 KB

## Abstract RNA interference (RNAi) is a potent mechanism for local silencing of gene expression and can be used to study loss‐of‐function phenotypes in mammalian cells. We used RNAi to knockdown specifically the expression of choline acetyltransferase (ChAT), the enzyme of acetylcholine biosynthes