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Silanediol-Based Inhibitor of Thermolysin.

✍ Scribed by Jaeseung Kim; Athanasios Glekas; Scott McN. Sieburth


Book ID
101946646
Publisher
John Wiley and Sons
Year
2003
Weight
175 KB
Volume
34
Category
Article
ISSN
0931-7597

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Binding of phosphorus-containing inhibit
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## Abstract Zinc endopeptidase thermolysin can be inhibited by a series of phosphorus‐containing peptide analogues, Cbz‐Gly‐__ψ__(PO~2~)‐X‐Leu‐Y‐R (ZG^P^(X)L(Y)R), where X = NH, O, or CH~2~; Y = NH or O; and R = Leu, Ala, Gly, Phe, H, or CH~3~. The affinity correlation as well as an X‐ray crystallo