✦ LIBER ✦
Silafunctional compounds in organic synthesis. 27. (Isopropoxydimethylsilyl)methyl grignard reagent: A new nucleophilic hydroxymethylating agent for aldehydes and ketones
✍ Scribed by Kohei Tamao; Neyoshi Ishida
- Book ID
- 104233774
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 222 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Nucleophilic hydroxymethylation of aldehydes and ketones has been achieved by the reaction with the (isopropoxydimethylsilyl)methyl Grignard reagent and the subsequent oxidative cleavage of the carbon-silicon bond.