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Signs of positive selection of somatic mutations in human cancers detected by EST sequence analysis

โœ Scribed by Vladimir N Babenko; Malay K Basu; Fyodor A Kondrashov; Igor B Rogozin; Eugene V Koonin


Book ID
115010931
Publisher
BioMed Central
Year
2006
Tongue
English
Weight
312 KB
Volume
6
Category
Article
ISSN
1471-2407

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Detection of a rare point mutation in Ki
โœ Grimmond, S. M. ;Raghavan, D. ;Russell, P. J. ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Springer ๐ŸŒ English โš– 615 KB

This paper represents the first report of a codon 59 mutation in Ki-ras from a spontaneous human transitional cell carcinoma of the bladder. Point mutations have the potential to activate the ras genes if they occur in critical coding regions. These include the sequences of codons 12, 13, 59, 61 and