Significant induction of spermidine/spermine N1-acetyltransferase without cytotoxicity by the growth-supporting polyamine analogue 1,12-dimethylspermine

Inhibition of cell growth in CaCO2 cells

Inhibition of cell growth in CaCO2 cells by the polyamine analogue N1,N12-bis(ethyl)spermine is preceded by a reduction in MYC oncoprotein levels

✍ Craig M. Berchtold; Pamela Tamez; Thomas W. Kensler; Robert A. Casero Jr. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 195 KB 👁 1 views

The polyamine analogue N 1 ,N 12 bis(ethyl)spermine (BESpm) is a potent inhibitor of cell proliferation and is representative of a class of agents currently in clinical trials. Previous studies have demonstrated that BESpm treatment can produce a decrease in the mRNA levels of the protooncogene c-my