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Significant decrease in telomerase activity during differentiation of human hepatoma cell lines

โœ Scribed by Nakamura, M.; Saito, H.; Ebinuma, H.; Takahashi, M.; Kaneko, F.; Wakabayashi, K.; Saito, Y.; Ishii, H.

Book ID
121899784
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
166 KB
Volume
114
Category
Article
ISSN
0016-5085

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A novel platinum compound inhibits telom
A novel platinum compound inhibits telomerase activity in vitro and reduces telomere length in a human hepatoma cell line
โœ Miho Furuta; Katsura Nozawa; Masaharu Takemura; Shunji Izuta; Takashi Murate; Ma ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 275 KB

## Abstract Telomerase activity is detectable in most human tumors but not in most normal somatic cells or tissues. Telomerase inhibition has, therefore, been proposed as a novel and potentially selective strategy for antitumor therapy. In the present study, we found that platinum compounds, includ