Significant correlation of peptidyl-prolyl isomerase overexpression in merkel cell carcinoma with overall survival of patients

✍ Scribed by Claudia Lill; Sven Schneider; Johannes Pammer; Robert Loewe; Wilhelm Gedlicka; Roland Houben; Gregor Heiduschka; Markus Brunner; Dietmar Thurnher

• Book ID: 102236316
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 448 KB
• Volume: 33
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/hed.21596

✦ Synopsis

Abstract

Background

An overexpression of PIN1, the peptidyl‐prolyl cis‐trans isomerase, might cause cell cycle arrest and growth inhibition by binding to the p53 protein, a process leading to p53 stabilization. The rationale of this retrospective analysis was to evaluate the expression pattern of PIN1 in Merkel cell carcinomas (MCCs) and its suitability as a prognostic factor.

Methods

Samples of 27 MCCs were immunhistochemically stained for PIN1 expression and correlated with overall and disease‐free survival of patients.

Results

All samples expressed PIN1. We showed a significantly better overall survival in patients with an overexpression of PIN1 than in patients with a weak PIN1 expression (p = .031), but expression was not significant for disease‐free survival (p = .821). The 5‐year overall survival rate was 14.4% in patients with weak and 50.9% in patients with overexpression of PIN1.

Conclusions

PIN1 seems to be a prognostic factor for a better overall survival rate of patients with MCC. © 2010 Wiley Periodicals, Inc. Head Neck, 2010