Significant correlation between expression of heat shock proteins 27, 70 and lymphocyte infiltration in esophageal squamous cell carcinoma
β Scribed by Masanobu Nakajima; Hiroyuki Kuwano; Tatsuya Miyazaki; Norihiro Masuda; Hiroyuki Kato
- Book ID
- 117467222
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 420 KB
- Volume
- 178
- Category
- Article
- ISSN
- 0304-3835
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## BACKGROUND. Heat shock proteins (HSPs) first were defined as proteins induced by heat shock and other environmental and pathophysiologic stresses and are implicated in protein-protein interactions such as folding, translocation, and prevention of inappropriate protein aggregation. Many of their
p27 Kip1 , one of the cyclin-dependent kinase (CDK) inhibitors (CDKIs), blocks progression from G 1 to S phase by binding cyclin D1-CDK4 and/or cyclin E-CDK2 and inhibiting their activities. Reflecting the function of p27 as a CDKI in vitro, a reduced expression of protein p27 has recently been repo