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Significance of the O6-methylguanine-DNA methyltransferase and glutathione S-transferase activity in the sera of patients with malignant and benign ovarian tumors

✍ Scribed by Tülay Akçay; Yıldız Dinçer; Zeynep Alademir; Kılıç Aydınlı; Macit Arvas; Fuat Demirkıran; Derin Kösebay


Book ID
116433936
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
116 KB
Volume
119
Category
Article
ISSN
0301-2115

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Methylation of the O6-methylguanine-DNA
✍ Rana Abdel-Fattah; Adam Glick; Ishtiaq Rehman; Patrick Maiberger; Henry Hennings 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 212 KB

## Abstract Hypermethylation of CpG sites within the promoter region of the __O^6^‐methylguanine‐DNA methyltransferase__ (__MGMT__) gene occurs frequently in human cancer, preventing both MGMT expression and repair of alkylation damage. To assess the role of MGMT in the development of mouse skin tu