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Significance of the expression of p27Kip1 in esophageal squamous cell carcinomas

✍ Scribed by Y. Kagawa; K. Yoshida; T. Hirai; T. Toge


Book ID
108980566
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
184 KB
Volume
13
Category
Article
ISSN
1120-8694

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p27 Kip1 , one of the cyclin-dependent kinase (CDK) inhibitors (CDKIs), blocks progression from G 1 to S phase by binding cyclin D1-CDK4 and/or cyclin E-CDK2 and inhibiting their activities. Reflecting the function of p27 as a CDKI in vitro, a reduced expression of protein p27 has recently been repo

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