Significance of serum lipoprotein-X and gammaglutamyltranspeptidase in the diagnosis of biliary atresia. A preliminary study in 27 cholestatic young infants
✍ Scribed by Y. Tazawa; M. Yamada; M. Nakagawa; K. Tada; T. Konno; R. Ohi; M. Kasai
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 344 KB
- Volume
- 145
- Category
- Article
- ISSN
- 0340-6997
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✦ Synopsis
As simple and nonsurgical means of differentiating biliary atresia (BA) from intrahepatic cholestasis of unknown origin (IC), liver function tests including serum lipoprotein-X (LP-X) and 7-glutamyltranspeptidase (GGTP) were done and evaluated for their usefulness in the diagnosis of 27 cholestatic Japanese young infants. Except for LP-X and GGTP levels (P < 0.01, P < 0.001), there were no significant differences between the BA (n = 11) and IC (n = 13) groups. When values of mean plus 4 standard deviations were used to differentiate BA from IC (89 rag/100 ml for LP-X and 194 IU/1 for GGTP), all BA patients gave positive results for either the critical LP-X of GGTP values. On the other hand, all IC patients gave negative results for both levels, although patients with a paucity of intrahepatic biliary ducts (n = 3) were also positive for either the critical LP-X or GGTP values. The combination test with serum LP-X and GGTP is recommended for helping to differentiate BA from IC in cholestatic young infants.