Significance of proliferating cell nuclear antigen (PCNA) expression in gastric cancer in relation to lymph node metastasis

✍ Scribed by Isozaki, Hiroshi; Okajima, Kunio; Ichinona, Tadashi; Fujii, Keizo; Nomura, Eiji; Izumi, Nobuyuki; Takeda, Yoshi

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 389 KB
• Volume: 61
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/(sici)1096-9098(199602)61:2<106::aid-jso4>3.0.co;2-g

✦ Synopsis

Proliferating cell nuclear antigen (PCNA) in gastric cancer was evaluated in relation to lymph node metastasis. A total of 125 gastric cancer patients who underwent gastrectomy were studied immunohistochemically. The PCNA-positive rate of the primary lesion with lymph node metastasis (47.6%) was significantly higher than that in those without metastasis (24.3%, P < O.OOO1). The PCNA-positive rate of early gastric cancer was significantly higher in lesions with lymph node metastasis (36.9%) than in lesions without lymph node metastasis (14.7%). However, there was no significant difference between lesions with and without lymph node metastasis in advanced gastric cancer. In addition, the PCNA-positive rate in metastatic lesions (44.6%) was significantly higher than that in the primary lesion (40.0%, P = 0.001). It is concluded that gastric cancer with higher tumor growth activity has a higher rate of lymph node metastasis. Cancer cells in the metastatic foci of lymph node have a higher proliferating activity than that in the primary lesion.