Significance of mutations in TGFBR2 and BAX in neoplastic progression and patient outcome in sporadic colorectal tumors with high-frequency microsatellite instability
✍ Scribed by Antonia M. Fernández-Peralta; Nargisse Nejda; Soledad Oliart; Vicente Medina; Mariano Moreno Azcoita; Juan J. González-Aguilera
- Book ID
- 113512516
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 200 KB
- Volume
- 157
- Category
- Article
- ISSN
- 0165-4608
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## Abstract High‐frequency microsatellite instability (MSI‐H) due to defective DNA mismatch repair occurs in the majority of hereditary nonpolyposis colorectal cancers (HNPCCs) and in a subset of sporadic malignant tumors. Clinicopathologic and genotypic features of MSI‐H colorectal tumors in HNPCC
## Abstract We have systematically retrieved genes with coding mononucleotide repeats from sequence databases and analyzed them for mutations in tumors with high levels of microsatellite instability (MSI‐H). We found somatic frameshift mutations in 7/13 genes previously not analyzed in MSI‐H tumors